A 48-Hour Holter ECG Study in Migraineurs during Usual Daily Activities

Abbreviations: ABP, ambulatory blood pressure; ECG, electrocardiogram; HF, high frequency heart rate fluctuation; LF, low frequency heart rate fluctuation; MESOR, midline estimating statistic of rhythm; MI, mean interval; RMSSD, root mean square successive differences; RR, between two QRS complexes in ECG; %RR50, the proportion of cycles during which the RR difference is > 50 ms; SD, standard deviation Autonomic dysfunction in migraineurs is of broad interest. In a patient with migraine, symptoms of autonomic disturbance can be observed, associated with or without migraine attack, such as blood flow in the cranial artery, Horner’s syndrome, etc. However, there is some controversy in the results of various studies on the autonomic nervous system. Abnormalities in the sympathetic nervous system have been fairly well documented in migraineurs during the headache-free phase, such as pupillary sympathetic hypofunction (Fanciullacci, 1979; Herman, 1983; Takeshima et al., 1987a), orthostatic hypotension (Gotoh et al., 1984; HavankaA 48-Hour Holter ECG Study in Migraineurs during Usual Daily Activities